Calcitriol Prevents Neuroinflammation and Reduces Blood-Brain Barrier Disruption and Local Macrophage/Microglia Activation

Calcitriol Prevents Neuroinflammation and Reduces Blood-Brain Barrier Disruption and Local Macrophage/Microglia Activation

Multiple sclerosis (MS) is a progressive disease of the central nervous system (CNS) that involves damage to the myelin sheath surrounding axons. MS therapy is based on immunomodulatory drugs that reduce disease recurrence and severity. Vitamin D is a hormone whose immunomodulatory ability has been...

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Bibliographic Details
Main Authors: Larissa Ragozo Cardoso de Oliveira, Luiza Ayumi Nishiyama Mimura, Thais Fernanda de Campos Fraga-Silva, Larissa Lumi Watanabe Ishikawa, Ana Angélica Henrique Fernandes, Sofia Fernanda Gonçalves Zorzella-Pezavento, Alexandrina Sartori
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
experimental autoimmune encephalomyelitis
blood-brain barrier
1,25-dihydroxyvitamin D3
inflammasome
oxidative stress
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00161/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.00161/full

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