CADEE: Computer-Aided Directed Evolution of Enzymes

CADEE: Computer-Aided Directed Evolution of Enzymes

The tremendous interest in enzymes as biocatalysts has led to extensive work in enzyme engineering, as well as associated methodology development. Here, a new framework for computer-aided directed evolution of enzymes (CADEE) is presented which allows a drastic reduction in the time necessary to pre...

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Bibliographic Details
Main Authors: Beat Anton Amrein, Fabian Steffen-Munsberg, Ireneusz Szeler, Miha Purg, Yashraj Kulkarni, Shina Caroline Lynn Kamerlin
Format: Article
Language:English
Published: International Union of Crystallography 2017-01-01
Series:IUCrJ
Subjects:
computational directed evolution
computational enzyme design
distributed computing
empirical valence bond
triosephosphate isomerase
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2052252516018017

Internet

http://scripts.iucr.org/cgi-bin/paper?S2052252516018017

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