A novel bispecific antibody targeting two overlapping epitopes in RBD improves neutralizing potency and breadth against SARS-CoV-2

A novel bispecific antibody targeting two overlapping epitopes in RBD improves neutralizing potency and breadth against SARS-CoV-2

SARS-CoV-2 has been evolving into a large number of variants, including the highly pathogenic Delta variant, and the currently prevalent Omicron subvariants with extensive evasion capability, which raises an urgent need to develop new broad-spectrum neutralizing antibodies. Herein, we engineer two I...

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Bibliographic Details
Main Authors: Hancong Sun, Lingyun Xia, Jianhua Li, Yuanyuan Zhang, Guanying Zhang, Ping Huang, Xingxing Wang, Yue Cui, Ting Fang, Pengfei Fan, Qiang Zhou, Xiangyang Chi, Changming Yu
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Emerging Microbes and Infections
Subjects:
SARS-CoV-2
Omicron subvariants
bispecific antibodies
IgG-(scFv)2
Cryo-EM
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2024.2373307

Internet

https://www.tandfonline.com/doi/10.1080/22221751.2024.2373307

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