Structure of mycobacterial CIII2CIV2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203)

Structure of mycobacterial CIII2CIV2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203)

The imidazopyridine telacebec, also known as Q203, is one of only a few new classes of compounds in more than 50 years with demonstrated antituberculosis activity in humans. Telacebec inhibits the mycobacterial respiratory supercomplex composed of complexes III and IV (CIII2CIV2). In mycobacterial e...

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Bibliographic Details
Main Authors: David J Yanofsky, Justin M Di Trani, Sylwia Król, Rana Abdelaziz, Stephanie A Bueler, Peter Imming, Peter Brzezinski, John L Rubinstein
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
Mycobacterium smegmatis
telacebec (Q203)
cryoEM
respiration
tuberculosis
structure
Online Access:https://elifesciences.org/articles/71959

Internet

https://elifesciences.org/articles/71959

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