Impaired aerobic capacity and premature fatigue preceding muscle weakness in the skeletal muscle Tfam-knockout mouse model

Impaired aerobic capacity and premature fatigue preceding muscle weakness in the skeletal muscle Tfam-knockout mouse model

Mitochondrial diseases are genetic disorders that lead to impaired mitochondrial function, resulting in exercise intolerance and muscle weakness. In patients, muscle fatigue due to defects in mitochondrial oxidative capacities commonly precedes muscle weakness. In mice, deletion of the fast-twitch s...

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Bibliographic Details
Main Authors: Benjamin Chatel, Sylvie Ducreux, Zeina Harhous, Nadia Bendridi, Isabelle Varlet, Augustin C. Ogier, Monique Bernard, Julien Gondin, Jennifer Rieusset, Håkan Westerblad, David Bendahan, Charlotte Gineste
Format: Article
Language:English
Published: The Company of Biologists 2021-09-01
Series:Disease Models & Mechanisms
Subjects:
mitochondrial myopathy
energy metabolism
muscle fatigue
exercise intolerance
muscle weakness
Online Access:http://dmm.biologists.org/content/14/9/dmm048981

Internet

http://dmm.biologists.org/content/14/9/dmm048981

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