Targeting RACK1 to alleviate TDP-43 and FUS proteinopathy-mediated suppression of protein translation and neurodegeneration

Targeting RACK1 to alleviate TDP-43 and FUS proteinopathy-mediated suppression of protein translation and neurodegeneration

Abstract TAR DNA-binding protein 43 (TDP-43) and Fused in Sarcoma/Translocated in Sarcoma (FUS) are ribonucleoproteins associated with pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Under physiological conditions, TDP-43 and FUS are predominantly lo...

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Bibliographic Details
Main Authors: Beibei Zhao, Catherine M. Cowan, Juliane A. Coutts, Darren D. Christy, Ananya Saraph, Shawn C. C. Hsueh, Stephen S. Plotkin, Ian R. Mackenzie, Johanne M. Kaplan, Neil R. Cashman
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Acta Neuropathologica Communications
Online Access:https://doi.org/10.1186/s40478-023-01705-8

Internet

https://doi.org/10.1186/s40478-023-01705-8

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