Polygenic risk scores for Alzheimer's disease in relation to cognitive change: A representative sample from the general population followed over 16 years.

Polygenic risk scores for Alzheimer's disease in relation to cognitive change: A representative sample from the general population followed over 16 years.

Background: Polygenic risk scores for Alzheimer's disease (AD-PRSs) have been associated with cognition. However, few studies have examined the effect of AD-PRS beyond the APOE gene, and the influence of genetic variants related to level of cognitive ability (COG-PRS) on cognitive performance o...

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Bibliographic Details
Main Authors: Jenna Najar, Valgeir Thorvaldsson, Silke Kern, Johan Skoog, Margda Waern, Henrik Zetterberg, Kaj Blennow, Ingmar Skoog, Anna Zettergren
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Neurobiology of Disease
Subjects:
Cognition
Polygenic risk scores
Cognitive decline
APOE genotype
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612300373X

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http://www.sciencedirect.com/science/article/pii/S096999612300373X

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