Intergenerational Inheritance of Hepatic Steatosis in a Mouse Model of Childhood Obesity: Potential Involvement of Germ-Line microRNAs

Intergenerational Inheritance of Hepatic Steatosis in a Mouse Model of Childhood Obesity: Potential Involvement of Germ-Line microRNAs

Childhood obesity increases the risk of developing metabolic syndrome later in life. Moreover, metabolic dysfunction may be inherited into the following generation through non-genomic mechanisms, with epigenetics as a plausible candidate. The pathways involved in the development of metabolic dysfunc...

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Bibliographic Details
Main Authors: Francesc Ribas-Aulinas, Sílvia Ribo, Eduard Casas, Marta Mourin-Fernandez, Marta Ramon-Krauel, Ruben Diaz, Carles Lerin, Susana G. Kalko, Tanya Vavouri, Josep C. Jimenez-Chillaron
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Nutrients
Subjects:
circadian rhythm
intergenerational epigenetic inheritance
childhood obesity
litter size reduction
DNA methylation
small non-coding RNAs
Online Access:https://www.mdpi.com/2072-6643/15/5/1241

Internet

https://www.mdpi.com/2072-6643/15/5/1241

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