FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells

FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells

Abstract Background The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in an inactive state and controls signaling activity. Removal of FKBP12 with drugs such as the FKBP-ligand FK506 enhances BMP activity in vario...

Full description

Bibliographic Details
Main Authors: Ingrid Quist-Løkken, Clara Andersson-Rusch, Martin Haugrud Kastnes, Jürgen Markus Kolos, Jerome Jatzlau, Hanne Hella, Oddrun Elise Olsen, Anders Sundan, Petra Knaus, Felix Hausch, Toril Holien
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Cell Communication and Signaling
Subjects:
Hematological cancer
SMAD
BMP
ACVR1
BMPRII
Tacrolimus
Online Access:https://doi.org/10.1186/s12964-022-01033-9

Internet

https://doi.org/10.1186/s12964-022-01033-9

Similar Items