Systematic functional analysis of rab GTPases reveals limits of neuronal robustness to environmental challenges in flies

Systematic functional analysis of rab GTPases reveals limits of neuronal robustness to environmental challenges in flies

Rab GTPases are molecular switches that regulate membrane trafficking in all cells. Neurons have particular demands on membrane trafficking and express numerous Rab GTPases of unknown function. Here, we report the generation and characterization of molecularly defined null mutants for all 26 rab gen...

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Bibliographic Details
Main Authors: Friederike E Kohrs, Ilsa-Maria Daumann, Bojana Pavlovic, Eugene Jennifer Jin, F Ridvan Kiral, Shih-Ching Lin, Filip Port, Heike Wolfenberg, Thomas F Mathejczyk, Gerit A Linneweber, Chih-Chiang Chan, Michael Boutros, P Robin Hiesinger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
Rab GTPase
mutant collection
Drosophila
Online Access:https://elifesciences.org/articles/59594

Internet

https://elifesciences.org/articles/59594

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