Multistability and predominant hybrid phenotypes in a four node mutually repressive network of Th1/Th2/Th17/Treg differentiation

Multistability and predominant hybrid phenotypes in a four node mutually repressive network of Th1/Th2/Th17/Treg differentiation

Abstract Elucidating the emergent dynamics of cellular differentiation networks is crucial to understanding cell-fate decisions. Toggle switch – a network of mutually repressive lineage-specific transcription factors A and B – enables two phenotypes from a common progenitor: (high A, low B) and (low...

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Main Authors: Atchuta Srinivas Duddu, Elizabeth Andreas, Harshavardhan BV, Kaushal Grover, Vivek Raj Singh, Kishore Hari, Siddharth Jhunjhunwala, Breschine Cummins, Tomas Gedeon, Mohit Kumar Jolly
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-024-00433-6

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https://doi.org/10.1038/s41540-024-00433-6

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