Familial Melanoma Phenotype With Xeroderma Pigmentosum Group C (XP-C) Genotype - The Putative Role of MC1R Polymorphism as Modifier

Familial Melanoma Phenotype With Xeroderma Pigmentosum Group C (XP-C) Genotype - The Putative Role of MC1R Polymorphism as Modifier

Introduction: Xeroderma pigmentosum (XP), a rare inherited condition, hallmarked by extreme sensitivity to sun exposure resulting in multiple skin cancers and non-malignant skin alterations is attributed to homozygous inactivating pathogenic variants (PVs) in DNA repair genes, predominantly the XPC...

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Bibliographic Details
Main Authors: Franciele Antonieta Bianchi Leidenz, Flavia Vasques Bittencourt, Williana Garcia Braga, Ellio Magno de Sá Araujo, Carolina Cavalieri Gomes, Vanessa de Fatima Bernardes, Eitan Friedman, Luiz De Marco
Format: Article
Language:English
Published: Mattioli1885 2024-01-01
Series:Dermatology Practical & Conceptual
Subjects:
xeroderma pigmentosum
familial melanoma
XPC
MC1R
modifier genes
Online Access:https://dpcj.org/index.php/dpc/article/view/3558

Internet

https://dpcj.org/index.php/dpc/article/view/3558

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