Context matters – Daxx and Atrx are not robust tumor suppressors in the murine endocrine pancreas

Context matters – Daxx and Atrx are not robust tumor suppressors in the murine endocrine pancreas

Genome sequencing has revealed the importance of epigenetic regulators in tumorigenesis. The genes encoding the chromatin remodeling complex DAXX:ATRX are frequently mutated in pancreatic neuroendocrine tumors; however, the underlying mechanisms of how mutations contribute to tumorigenesis are only...

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Bibliographic Details
Main Authors: Chang Sun, Jeannelyn S. Estrella, Elizabeth M. Whitley, Gilda P. Chau, Guillermina Lozano, Amanda R. Wasylishen
Format: Article
Language:English
Published: The Company of Biologists 2022-08-01
Series:Disease Models & Mechanisms
Subjects:
daxx
atrx
men1
pancreatic neuroendocrine tumor
mouse model
Online Access:http://dmm.biologists.org/content/15/8/dmm049552

Internet

http://dmm.biologists.org/content/15/8/dmm049552

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