Liposomal formulations of carboplatin injected by convection-enhanced delivery increases the median survival time of F98 glioma bearing rats

Liposomal formulations of carboplatin injected by convection-enhanced delivery increases the median survival time of F98 glioma bearing rats

Abstract Background Effectiveness of chemotherapy for treating glioblastoma (GBM) brain tumors is hampered by the blood–brain barrier which limits the entry into the brain of most drugs from the blood. To bypass this barrier, convection-enhanced delivery (CED) was proposed to directly inject drugs i...

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Bibliographic Details
Main Authors: Minghan Shi, Malathi Anantha, Mohamed Wehbe, Marcel B. Bally, David Fortin, Laurent-Olivier Roy, Gabriel Charest, Maxime Richer, Benoit Paquette, Léon Sanche
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Journal of Nanobiotechnology
Subjects:
Brain tumor
Carboplatin
Convection-enhanced delivery
Glioblastoma
Liposome
Online Access:http://link.springer.com/article/10.1186/s12951-018-0404-8

Internet

http://link.springer.com/article/10.1186/s12951-018-0404-8

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