Diversity of Dominant Peripheral T Cell Receptor Clone and Soluble Immune Checkpoint Proteins Associated With Clinical Outcomes Following Immune Checkpoint Inhibitor Treatment in Advanced Cancers

Diversity of Dominant Peripheral T Cell Receptor Clone and Soluble Immune Checkpoint Proteins Associated With Clinical Outcomes Following Immune Checkpoint Inhibitor Treatment in Advanced Cancers

Dynamic changes of the peripheral T cell receptor (TCR) and soluble receptors and ligands (sRLs) have the potential to be used as biomarkers to monitor the evolution of the immune system in tumor patients undergoing immunotherapy. These functional biomarkers could be used to predict immune response...

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Bibliographic Details
Main Authors: Ye Li, Jiaqian Wang, Liangliang Wu, Xiaoting Li, Xiaoyun Zhang, Guoqing Zhang, Shengqiang Xu, Shengjie Sun, Shunchang Jiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
advanced cancer
immune checkpoint inhibitors
T cell repertoire
high-throughput sequencing
soluble checkpoint protein
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.649343/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.649343/full

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