Differences in bioavailability and cognitive-enhancing activity exerted by different crystal polymorphs of latrepirdine (Dimebon®)

Differences in bioavailability and cognitive-enhancing activity exerted by different crystal polymorphs of latrepirdine (Dimebon®)

Introduction: Pharmacokinetic characteristics as well as cognitive-enhancing nootropic activity of latrepirdine (Dimebon®) in relationship with its polymorphic forms have been studied in SD and Wistar rats.Methods: The pharmacokinetics of six polymorphs (A, B, C, D, E, F) of latrepirdine were studie...

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Bibliographic Details
Main Authors: Boris I. Gorin, Elena A. Tukhovskaya, Alina M. Ismailova, Gulsara A. Slashcheva, Oksana A. Lenina, Konstantin A. Petrov, Ilya V. Kazeev, Arkady N. Murashev
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Pharmacology
Subjects:
latrepirdine
polymorph
rat
pharmacokinetics
scopolamine
passive avoidance test
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1091858/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1091858/full

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