HA N193D substitution in the HPAI H5N1 virus alters receptor binding affinity and enhances virulence in mammalian hosts

HA N193D substitution in the HPAI H5N1 virus alters receptor binding affinity and enhances virulence in mammalian hosts

ABSTRACTDuring the 2021/2022 winter season, we isolated highly pathogenic avian influenza (HPAI) H5N1 viruses harbouring an amino acid substitution from Asparagine(N) to Aspartic acid (D) at residue 193 of the hemagglutinin (HA) receptor binding domain (RBD) from migratory birds in South Korea. Here...

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Bibliographic Details
Main Authors: Seung-Gyu Jang, Young-Il Kim, Mark Anthony B. Casel, Jeong Ho Choi, Ju Ryeon Gil, Rare Rollon, Eun-Ha Kim, Se-Mi Kim, Ho Young Ji, Dong Bin Park, Jungwon Hwang, Jae-Woo Ahn, Myung Hee Kim, Min-Suk Song, Young Ki Choi
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Emerging Microbes and Infections
Subjects:
HPAI H5N8 virus
Clade 2.3.4.4
reassortant
pathogenecity
South Korea
Influenza infections
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2024.2302854

Internet

https://www.tandfonline.com/doi/10.1080/22221751.2024.2302854

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