Differential Effects of Fkbp4 and Fkbp5 on Regulation of the <i>Proopiomelanocortin</i> Gene in Murine AtT-20 Corticotroph Cells

Differential Effects of Fkbp4 and Fkbp5 on Regulation of the <i>Proopiomelanocortin</i> Gene in Murine AtT-20 Corticotroph Cells

The hypothalamic-pituitary-adrenal axis is stimulated in response to stress. When activated, it is suppressed by the negative feedback effect of glucocorticoids. Glucocorticoids directly inhibit <i>proopiomelanocortin</i> (<i>Pomc</i>) gene expression in the pituitary. Glucoc...

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Bibliographic Details
Main Authors: Kazunori Kageyama, Yasumasa Iwasaki, Yutaka Watanuki, Kanako Niioka, Makoto Daimon
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
adrenocorticotropic hormone
proopiomelanocortin
pituitary
Fkbp
glucocorticoid
Online Access:https://www.mdpi.com/1422-0067/22/11/5724

Internet

https://www.mdpi.com/1422-0067/22/11/5724

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