BMI1 promotes osteosarcoma proliferation and metastasis by repressing the transcription of SIK1

BMI1 promotes osteosarcoma proliferation and metastasis by repressing the transcription of SIK1

Abstract Background Osteosarcoma (OS) is the most common malignant tumor of bone, and the clinical efficacy of current treatments and associated survival rates need to be further improved by employing novel therapeutic strategies. Although various studies have shown that BMI1 protein is universally...

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Bibliographic Details
Main Authors: Qiang Wang, Yinghui Wu, Meng Lin, Gaigai Wang, Jinyan Liu, Min Xie, Bo Zheng, Cong Shen, Jun Shen
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Cancer Cell International
Subjects:
Osteosarcoma(OS)
BMI1
Proliferation
Metastasis
SIK1
Histone modification
Online Access:https://doi.org/10.1186/s12935-022-02552-8

Internet

https://doi.org/10.1186/s12935-022-02552-8

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