Predation Stress Causes Excessive Aggression in Female Mice with Partial Genetic Inactivation of Tryptophan Hydroxylase-2: Evidence for Altered Myelination-Related Processes

Predation Stress Causes Excessive Aggression in Female Mice with Partial Genetic Inactivation of Tryptophan Hydroxylase-2: Evidence for Altered Myelination-Related Processes

The interaction between brain serotonin (5-HT) deficiency and environmental adversity may predispose females to excessive aggression. Specifically, complete inactivation of the gene encoding tryptophan hydroxylase-2 (<i>Tph2</i>) results in the absence of neuronal 5-HT synthesis and exce...

Full description

Bibliographic Details
Main Authors: Evgeniy Svirin, Ekaterina Veniaminova, João Pedro Costa-Nunes, Anna Gorlova, Aleksei Umriukhin, Allan V. Kalueff, Andrey Proshin, Daniel C. Anthony, Andrey Nedorubov, Anna Chung Kwan Tse, Susanne Walitza, Lee Wei Lim, Klaus-Peter Lesch, Tatyana Strekalova
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
tryptophan hydroxylase-2 (<i>Tph2</i>)
female aggression
5-HT receptors
glycogen synthase kinase-3 β (GSK-3β)
myelination
predation stress
Online Access:https://www.mdpi.com/2073-4409/11/6/1036

Internet

https://www.mdpi.com/2073-4409/11/6/1036

Similar Items