14-3-3 Binding and Sumoylation Concur to the Down-Modulation of β-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia.

14-3-3 Binding and Sumoylation Concur to the Down-Modulation of β-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia.

The down-modulation of the β-catenin antagonist Chibby 1 (CBY1) associated with the BCR-ABL1 fusion gene of chronic myeloid leukemia (CML) contributes to the aberrant activation of β-catenin, particularly in leukemic stem cells (LSC) resistant to tyrosine kinase (TK) inhibitors. It is, at least part...

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Bibliographic Details
Main Authors: Manuela Mancini, Elisa Leo, Ken-Ichi Takemaru, Virginia Campi, Fausto Castagnetti, Simona Soverini, Caterina De Benedittis, Gianantonio Rosti, Michele Cavo, Maria Alessandra Santucci, Giovanni Martinelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4492953?pdf=render

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http://europepmc.org/articles/PMC4492953?pdf=render

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