Neuroprotection and immunomodulation following intraspinal axotomy of motoneurons by treatment with adult mesenchymal stem cells

Neuroprotection and immunomodulation following intraspinal axotomy of motoneurons by treatment with adult mesenchymal stem cells

Abstract Background Treatment of spinal cord injury is dependent on neuronal survival, appropriate synaptic circuit preservation, and inflammatory environment management. In this sense, mesenchymal stem cell (MSC) therapy is a promising tool that can reduce glial reaction and provide trophic factors...

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Bibliographic Details
Main Authors: A. B. Spejo, G. B. Chiarotto, A. D. F. Ferreira, D. A. Gomes, R. S. Ferreira, B. Barraviera, A. L. R. Oliveira
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Neuroinflammation
Subjects:
Spinal cord
Funiculus cut
Motoneuron
Astrogliosis
Microglial reaction
Immunomodulation
Online Access:http://link.springer.com/article/10.1186/s12974-018-1268-4

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http://link.springer.com/article/10.1186/s12974-018-1268-4

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