Design, Synthesis, and Evaluation of a Set of Carboxylic Acid and Phosphate Prodrugs Derived from HBV Capsid Protein Allosteric Modulator NVR 3-778

Design, Synthesis, and Evaluation of a Set of Carboxylic Acid and Phosphate Prodrugs Derived from HBV Capsid Protein Allosteric Modulator NVR 3-778

Hepatitis B virus (HBV) capsid protein (Cp) is necessary for viral replication and the maintenance of viral persistence, having become an attractive target of anti-HBV drugs. To improve the water solubility of HBV capsid protein allosteric modulator (CpAM) NVR 3-778, a series of novel carboxylic aci...

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Bibliographic Details
Main Authors: Xiangkai Ji, Xiangyi Jiang, Chisa Kobayashi, Yujie Ren, Lide Hu, Zhen Gao, Dongwei Kang, Ruifang Jia, Xujie Zhang, Shujie Zhao, Koichi Watashi, Xinyong Liu, Peng Zhan
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
HBV
capsid
CpAM
NVR 3-778
prodrug strategy
water solubility
Online Access:https://www.mdpi.com/1420-3049/27/18/5987

Internet

https://www.mdpi.com/1420-3049/27/18/5987

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