The Role of Fibrogenesis and Extracellular Matrix Proteins in the Pathogenesis of Graves’ Ophthalmopathy

The Role of Fibrogenesis and Extracellular Matrix Proteins in the Pathogenesis of Graves’ Ophthalmopathy

Graves’ ophthalmopathy (GO), or thyroid eye disease (TED), is the most frequent extrathyroidal manifestation of Graves’ disease (GD). Inflammation and subsequent aberrant tissue remodeling with fibrosis are important pathogenesis. There are many proposed mechanisms and molecular pathways contributin...

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Bibliographic Details
Main Authors: Hsun-I Chiu, Shi-Bei Wu, Chieh-Chih Tsai
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
Graves’ orbital fibroblasts
Graves’ ophthalmopathy (GO)
transforming growth factor-β1 (TGF-β1)
oxidative stress
endoplasmic reticulum (ER)
epigenetics
Online Access:https://www.mdpi.com/1422-0067/25/6/3288

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https://www.mdpi.com/1422-0067/25/6/3288

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