Potential protective role of astrocytes in the pathogenesis of astrocyte-mediated synaptic plasticity of Parkinson’s disease
Astrocytes are the most abundant glia in the central nervous system that play a significant role in disease. Recently, it roles of synaptic plasticity in neuropathological damages have been questioned whether the structural and functional plasticity of synapses contributes to the pathogenesis of...
| Main Authors: | , |
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| Format: | Article |
| Sprog: | English |
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IMR Press
2021-06-01
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| Serier: | Journal of Integrative Neuroscience |
| Fag: | |
| Online adgang: | https://jin.imrpress.com/fileup/1757-448X/PDF/1625014748470-583048528.pdf |
| Summary: | Astrocytes are the most abundant glia in the
central nervous system that play a significant role in disease. Recently, it
roles of synaptic plasticity in neuropathological damages have been questioned
whether the structural and functional plasticity of synapses contributes to the
pathogenesis of Parkinson’s disease. The regulation of synaptic plasticity by
astrocytes has also been widely researched based on astrocytes regulate synaptic
plasticity by releasing Adenosine triphosphate, glutamate, and D-serine. We
discuss the possible role of astrocytes in the regulation of synaptic plasticity,
which may provide a new direction to Parkinson’s disease treatment. |
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| ISSN: | 1757-448X |