Extracellular vesicles secreted from bone metastatic renal cell carcinoma promote angiogenesis and endothelial gap formation in bone marrow in a time-dependent manner in a preclinical mouse model

Extracellular vesicles secreted from bone metastatic renal cell carcinoma promote angiogenesis and endothelial gap formation in bone marrow in a time-dependent manner in a preclinical mouse model

IntroductionBone is a major metastatic site of renal cell carcinoma (RCC). Recently, it is well recognized that bone metastatic tumor cells remodel bone marrow vasculature. However, the precise mechanism underlying cell-cell communication between bone metastatic RCC and the cells in bone marrow rema...

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Bibliographic Details
Main Authors: Masashi Takeda, Hiromasa Sakamoto, Noboru Shibasaki, Tomohiro Fukui, Toshihiro Magaribuchi, Takayuki Sumiyoshi, Noriaki Utsunomiya, Atsuro Sawada, Takayuki Goto, Takashi Kobayashi, Koji Ueda, Toshinari Yamasaki, Osamu Ogawa, Shusuke Akamatsu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Oncology
Subjects:
extracellular vesicle (EV)
renal cell carcinoma (RCC)
bone metastasis (BM)
angiogenesis
proteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1139049/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1139049/full

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