The STIM1/2-Regulated Calcium Homeostasis Is Impaired in Hippocampal Neurons of the 5xFAD Mouse Model of Alzheimer’s Disease

The STIM1/2-Regulated Calcium Homeostasis Is Impaired in Hippocampal Neurons of the 5xFAD Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common cause of age-related dementia. Neuronal calcium homeostasis impairment may contribute to AD. Here we demonstrated that voltage-gated calcium (VGC) entry and store-operated calcium (SOC) entry regulated by calcium sensors of intracellular calcium stores STI...

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Bibliographic Details
Main Authors: Ksenia Skobeleva, Alexey Shalygin, Elena Mikhaylova, Irina Guzhova, Maria Ryazantseva, Elena Kaznacheyeva
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
5xFAD
hippocampal cultures
store-operated calcium entry
voltage-gated calcium entry
STIM1
Online Access:https://www.mdpi.com/1422-0067/23/23/14810

Internet

https://www.mdpi.com/1422-0067/23/23/14810

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