Circadian rhythms of Per2::Luc in individual primary mouse hepatocytes and cultures.

BACKGROUND: Hepatocytes, the parenchymal cells of the liver, express core clock genes, such as Period2 and Cryptochrome2, which are involved in the transcriptional/translational feedback loop of the circadian clock. Whether or not the liver is capable of sustaining rhythms independent of a central p...

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Bibliographic Details
Main Authors: Casey J Guenthner, Martha E Luitje, Lorna A Pyle, Penny C Molyneux, Jimmy K Yu, Alexander S Li, Tanya L Leise, Mary E Harrington
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3911982?pdf=render