Activation of the human insulin receptor by non-insulin-related peptides

Activation of the human insulin receptor by non-insulin-related peptides

The regulation of plasma glucose levels is effected by insulin. Here, the authors reveal atomic detail of how peptides distinct from insulin bind to and activate the insulin receptor, with implications for design of small-molecule insulin mimetics.

Bibliographic Details
Main Authors: Nicholas S. Kirk, Qi Chen, Yingzhe Ginger Wu, Anastasia L. Asante, Haitao Hu, Juan F. Espinosa, Francisco Martínez-Olid, Mai B. Margetts, Faiz A. Mohammed, Vladislav V. Kiselyov, David G. Barrett, Michael C. Lawrence
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33315-8

Internet

https://doi.org/10.1038/s41467-022-33315-8

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