Multimodal analysis of cell-free DNA whole-methylome sequencing for cancer detection and localization

Multimodal analysis of cell-free DNA whole-methylome sequencing for cancer detection and localization

Abstract Multimodal epigenetic characterization of cell-free DNA (cfDNA) could improve the performance of blood-based early cancer detection. However, integrative profiling of cfDNA methylome and fragmentome has been technologically challenging. Here, we adapt an enzyme-mediated methylation sequenci...

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Bibliographic Details
Main Authors: Fenglong Bie, Zhijie Wang, Yulong Li, Wei Guo, Yuanyuan Hong, Tiancheng Han, Fang Lv, Shunli Yang, Suxing Li, Xi Li, Peiyao Nie, Shun Xu, Ruochuan Zang, Moyan Zhang, Peng Song, Feiyue Feng, Jianchun Duan, Guangyu Bai, Yuan Li, Qilin Huai, Bolun Zhou, Yu S. Huang, Weizhi Chen, Fengwei Tan, Shugeng Gao
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41774-w

Internet

https://doi.org/10.1038/s41467-023-41774-w

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