β<sub>2</sub>-Integrin Adhesive Bond Tension under Shear Stress Modulates Cytosolic Calcium Flux and Neutrophil Inflammatory Response

β<sub>2</sub>-Integrin Adhesive Bond Tension under Shear Stress Modulates Cytosolic Calcium Flux and Neutrophil Inflammatory Response

On arrested neutrophils a focal adhesive cluster of ~200 high affinity (HA) β<sub>2</sub>-integrin bonds under tension is sufficient to trigger Ca<sup>2+</sup> flux that signals an increase in activation in direct proportion to increments in shear stress. We reasoned that a t...

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Bibliographic Details
Main Authors: Vasilios Aris Morikis, Szu Jung Chen, Julianna Madigan, Myung Hyun Jo, Lisette Caroline Werba, Taekjip Ha, Scott Irwin Simon
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
neutrophils
tension gauge tethers
β<sub>2</sub>-integrin
Online Access:https://www.mdpi.com/2073-4409/11/18/2822

Internet

https://www.mdpi.com/2073-4409/11/18/2822

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