CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors

Abstract As the most prevalent neurodevelopmental disorders in children, autism spectrum disorders (ASD) are characterized by deficits in language development, social interaction, and repetitive behaviors or inflexible interests. Contactin associated protein like 2 (CNTNAP2), encoding a single trans...

Full description

Bibliographic Details
Main Authors: Jing Zhang, Fang Cai, Renbin Lu, Xiaoliang Xing, Lu Xu, Kunyang Wu, Zishan Gong, Qing Zhang, Yun Zhang, Mengen Xing, Weihong Song, Jia-Da Li
Format: Article
Language:English
Published: Nature Publishing Group 2023-06-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01431-6