FBXW7 suppresses HMGB1-mediated innate immune signaling to attenuate hepatic inflammation and insulin resistance in a mouse model of nonalcoholic fatty liver disease

FBXW7 suppresses HMGB1-mediated innate immune signaling to attenuate hepatic inflammation and insulin resistance in a mouse model of nonalcoholic fatty liver disease

Abstract Background Innate immune dysfunction contributes to the development and progression of nonalcoholic fatty liver disease (NAFLD), however, its pathogenesis is still incompletely understood. Identifying the key innate immune component responsible for the pathogenesis of NAFLD and clarifying t...

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Bibliographic Details
Main Authors: Cheng Zhang, Feng Chen, Li Feng, Qun Shan, Gui-Hong Zheng, Yong-Jian Wang, Jun Lu, Shao-Hua Fan, Chun-Hui Sun, Dong-Mei Wu, Meng-Qiu Li, Bin Hu, Qing-Qing Wang, Zi-Feng Zhang, Yuan-Lin Zheng
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Molecular Medicine
Subjects:
FBXW7
HMGB1
Innate immunity
Metaflammation
Insulin resistance
NAFLD
Online Access:http://link.springer.com/article/10.1186/s10020-019-0099-9

Internet

http://link.springer.com/article/10.1186/s10020-019-0099-9

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