HSDL2 knockdown promotes the progression of cholangiocarcinoma by inhibiting ferroptosis through the P53/SLC7A11 axis

HSDL2 knockdown promotes the progression of cholangiocarcinoma by inhibiting ferroptosis through the P53/SLC7A11 axis

Abstract Background Human hydroxysteroid dehydrogenase-like 2 (HSDL2), which regulates cancer progression, is involved in lipid metabolism. However, the role of HSDL2 in cholangiocarcinoma (CCA) and the mechanism by which it regulates CCA progression by modulating ferroptosis are unclear. Methods HS...

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Bibliographic Details
Main Authors: Shuoshuo Ma, Yang Ma, Feiyu Qi, Jiasheng Lei, Fangfang Chen, Wanliang Sun, Dongdong Wang, Shuo Zhou, Zhong Liu, Zheng Lu, Dengyong Zhang
Format: Article
Language:English
Published: BMC 2023-09-01
Series:World Journal of Surgical Oncology
Subjects:
HSDL2
Cholangiocarcinoma
Proliferation
Ferroptosis
Prognosis
Online Access:https://doi.org/10.1186/s12957-023-03176-6

Internet

https://doi.org/10.1186/s12957-023-03176-6

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