Nectin-4 promotes osteosarcoma progression and metastasis through activating PI3K/AKT/NF-κB signaling by down-regulation of miR-520c-3p

Nectin-4 promotes osteosarcoma progression and metastasis through activating PI3K/AKT/NF-κB signaling by down-regulation of miR-520c-3p

Abstract Purpose Nectin-4 is specifically up-regulated in various tumors, exert crucial effects on tumor occurrence and development. Nevertheless, the role and molecular mechanism of Nectin-4 in osteosarcoma (OS) are rarely studied. Methods The expression of Nectin-4 and its relationship with clinic...

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Bibliographic Details
Main Authors: Yongheng Liu, Guanghao Li, Yan Zhang, Lili Li, Yanting Zhang, Xiaoyu Huang, Xianfu Wei, Peng Zhou, Ming Liu, Gang zhao, Jinyan Feng, Guowen Wang
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Cancer Cell International
Subjects:
Nectin-4
Osteosarcoma
Metastasis
PI3K/AKT/NF-κB
miR-520c-3p
Online Access:https://doi.org/10.1186/s12935-022-02669-w

Internet

https://doi.org/10.1186/s12935-022-02669-w

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