Conjugates of 1'-Aminoferrocene-1-carboxylic Acid and Proline: Synthesis, Conformational Analysis and Biological Evaluation

Conjugates of 1'-Aminoferrocene-1-carboxylic Acid and Proline: Synthesis, Conformational Analysis and Biological Evaluation

Our previous studies showed that alteration of dipeptides Y-Fca-Ala-OMe (III) into Y-Ala-Fca-OMe (IV) (Y = Ac, Boc; Fca = 1'-aminoferrocene-1-carboxylic acid) significantly influenced their conformational space. The novel bioconjugates Y-Fca-Pro-OMe (1, Y = Ac; 2, Y = Boc) and Y-Pro-Fca-OMe (3,...

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Bibliographic Details
Main Authors: Monika Kovačević, Krešimir Molčanov, Kristina Radošević, Višnja Gaurina Srček, Sunčica Roca, Alan Čače, Lidija Barišić
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:Molecules
Subjects:
ferrocene
proline
peptidomimetic
intramolecular hydrogen bond
conformational analysis
X-ray crystallography
anticancer activity
Online Access:http://www.mdpi.com/1420-3049/19/8/12852

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http://www.mdpi.com/1420-3049/19/8/12852

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