Alterations in the phenotype of neocortical pyramidal cells in the Dyrk1A+/− mouse

Alterations in the phenotype of neocortical pyramidal cells in the Dyrk1A+/− mouse

The gene encoding the dual-specificity tyrosine-regulated kinase DYRK1A maps to the chromosomal segment HSA21q22.2, which lies within the Down syndrome critical region. The reduction in brain size and behavioral defects observed in mice lacking one copy of the murine homologue Dyrk1A (Dyrk1A+/−) sup...

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Bibliographic Details
Main Authors: R. Benavides-Piccione, M. Dierssen, I. Ballesteros-Yáñez, M. Martínez de Lagrán, M.L. Arbonés, V. Fotaki, J. DeFelipe, G.N. Elston
Format: Article
Language:English
Published: Elsevier 2005-10-01
Series:Neurobiology of Disease
Subjects:
Down syndrome critical region
Genetically modified mice
Mental retardation
Microcephaly
Monosomy 21
Neocortex
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105000665

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http://www.sciencedirect.com/science/article/pii/S0969996105000665

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