DNA immunization site determines the level of gene expression and the magnitude, but not the type of the induced immune response.

DNA immunization site determines the level of gene expression and the magnitude, but not the type of the induced immune response.

Optimization of DNA vaccine delivery improves the potency of the immune response and is crucial to clinical success. Here, we inquired how such optimization impacts the magnitude of the response, its specificity and type. BALB/c mice were DNA-immunized with two model immunogens, HIV-1 protease and r...

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Bibliographic Details
Main Authors: Stefan Petkov, Elizaveta Starodubova, Anastasia Latanova, Athina Kilpeläinen, Oleg Latyshev, Simons Svirskis, Britta Wahren, Francesca Chiodi, Ilya Gordeychuk, Maria Isaguliants
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5986124?pdf=render

Internet

http://europepmc.org/articles/PMC5986124?pdf=render

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