Assessing Chemical-Induced Liver Injury In Vivo From In Vitro Gene Expression Data in the Rat: The Case of Thioacetamide Toxicity

Assessing Chemical-Induced Liver Injury In Vivo From In Vitro Gene Expression Data in the Rat: The Case of Thioacetamide Toxicity

Consumers are exposed to thousands of chemicals with potentially adverse health effects. However, these chemicals will never be tested for toxicity because of the immense resources needed for animal-based (in vivo) toxicological studies. Today, there are no viable in vitro alternatives to these type...

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Bibliographic Details
Main Authors: Patric Schyman, Richard L. Printz, Shanea K. Estes, Tracy P. O’Brien, Masakazu Shiota, Anders Wallqvist
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Genetics
Subjects:
predictive toxicology
RNA-seq
thioacetamide
toxicogenomics
fibrosis
in vitro-in vivo correlations
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01233/full

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https://www.frontiersin.org/article/10.3389/fgene.2019.01233/full

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