Semi-Synthetic Dihydrotestosterone Derivatives Modulate Inherent Multidrug Resistance and Sensitize Colon Cancer Cells to Chemotherapy

Semi-Synthetic Dihydrotestosterone Derivatives Modulate Inherent Multidrug Resistance and Sensitize Colon Cancer Cells to Chemotherapy

Multidrug resistance (MDR) is a serious hurdle to successful cancer therapy. Here, we examined the efficiency of novel semi-synthetic dihydrotestosterone derivatives, more specifically androstano-arylpyrimidines in inhibiting the efflux activity of ATP-binding cassette (ABC) transporters and sensiti...

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Bibliographic Details
Main Authors: Ferenc István Nagy, Dóra Izabella Adamecz, Ádám Baji, Ágnes Kiricsi, Ildikó Huliák, Andrea Rónavári, Zoltán Kónya, Éva Frank, Mohana Krishna Gopisetty, Mónika Kiricsi
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
multidrug resistance
drug-resistant cancer
ABC transporters
combination therapy
pyrimidine-fused androgens
endoplasmic reticulum stress
Online Access:https://www.mdpi.com/1999-4923/15/2/584

Internet

https://www.mdpi.com/1999-4923/15/2/584

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