Monocrotophos induces the expression and activity of xenobiotic metabolizing enzymes in pre-sensitized cultured human brain cells.

Monocrotophos induces the expression and activity of xenobiotic metabolizing enzymes in pre-sensitized cultured human brain cells.

The expression and metabolic profile of cytochrome P450s (CYPs) is largely missing in human brain due to non-availability of brain tissue. We attempted to address the issue by using human brain neuronal (SH-SY5Y) and glial (U373-MG) cells. The expression and activity of CYP1A1, 2B6 and 2E1 were carr...

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Bibliographic Details
Main Authors: Vinay K Tripathi, Vivek Kumar, Abhishek K Singh, Mahendra P Kashyap, Sadaf Jahan, Ankita Pandey, Sarfaraz Alam, Feroz Khan, Vinay K Khanna, Sanjay Yadav, Mohtshim Lohani, Aditya B Pant
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3963866?pdf=render

Internet

http://europepmc.org/articles/PMC3963866?pdf=render

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