Toll-like receptor 4 (TLR4) is the major pattern recognition receptor triggering the protective effect of a Candida albicans extracellular vesicle-based vaccine prototype in murine systemic candidiasis

Toll-like receptor 4 (TLR4) is the major pattern recognition receptor triggering the protective effect of a Candida albicans extracellular vesicle-based vaccine prototype in murine systemic candidiasis

ABSTRACT Systemic candidiasis remains a significant public health concern worldwide, with high mortality rates despite available antifungal drugs. Drug-resistant strains add to the urgency for alternative therapies. In this context, vaccination has reemerged as a prominent immune-based strategy. Ext...

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Bibliographic Details
Main Authors: Leandro Honorato, Jhon J. Artunduaga Bonilla, Alessandro F. Valdez, Susana Frases, Glauber Ribeiro de Sousa Araújo, Albaniza Liuane Ribeiro do Nascimento Sabino, Natalia Martins da Silva, Larissa Ribeiro, Marina da Silva Ferreira, Julio Kornetz, Marcio L. Rodrigues, Iain Cunningham, Neil A. R. Gow, Attila Gacser, Allan J. Guimarães, Fabianno F. Dutra, Leonardo Nimrichter
Format: Article
Language:English
Published: American Society for Microbiology 2024-08-01
Series:mSphere
Subjects:
Candida albicans
extracellular vesicles
vaccines
Online Access:https://journals.asm.org/doi/10.1128/msphere.00467-24

Internet

https://journals.asm.org/doi/10.1128/msphere.00467-24

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