Dysregulation of ErbB4 Signaling Pathway in the Dorsal Hippocampus after Neonatal Hypoxia-Ischemia and Late Deficits in PV<sup>+</sup> Interneurons, Synaptic Plasticity and Working Memory

Dysregulation of ErbB4 Signaling Pathway in the Dorsal Hippocampus after Neonatal Hypoxia-Ischemia and Late Deficits in PV<sup>+</sup> Interneurons, Synaptic Plasticity and Working Memory

Neonatal hypoxic-ischemic (HI) injury leads to deficits in hippocampal parvalbumin (PV)<sup>+</sup> interneurons (INs) and working memory. Therapeutic hypothermia (TH) does not prevent these deficits. ErbB4 supports maturation and maintenance of PV<sup>+</sup> IN. Thus, we hy...

Full description

Bibliographic Details
Main Authors: Harisa Spahic, Pritika Parmar, Sarah Miller, Paul Casey Emerson, Charles Lechner, Mark St. Pierre, Neetika Rastogi, Michael Nugent, Sarah Ann Duck, Alfredo Kirkwood, Raul Chavez-Valdez
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
parvalbumin
neuregulin-1
long-term depression
long-term potentiation
Akt
Online Access:https://www.mdpi.com/1422-0067/24/1/508

Internet

https://www.mdpi.com/1422-0067/24/1/508

Similar Items