Amino acid transporter SLC38A5 regulates developmental and pathological retinal angiogenesis

Amino acid transporter SLC38A5 regulates developmental and pathological retinal angiogenesis

Amino acid (AA) metabolism in vascular endothelium is important for sprouting angiogenesis. SLC38A5 (solute carrier family 38 member 5), an AA transporter, shuttles neutral AAs across cell membrane, including glutamine, which may serve as metabolic fuel for proliferating endothelial cells (ECs) to p...

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Bibliographic Details
Main Authors: Zhongxiao Wang, Felix Yemanyi, Alexandra K Blomfield, Kiran Bora, Shuo Huang, Chi-Hsiu Liu, William R Britton, Steve S Cho, Yohei Tomita, Zhongjie Fu, Jian-xing Ma, Wen-hong Li, Jing Chen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-12-01
Series:eLife
Subjects:
amino acids
angiogenesis
endothelial cells
neovascularization
retinopathy
SLC38A5
Online Access:https://elifesciences.org/articles/73105

Internet

https://elifesciences.org/articles/73105

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