Biology of Adeno-Associated Viral Vectors in the Central Nervous System

Gene therapy is a promising approach for treating a spectrum of neurological and neurodegenerative disorders by delivering corrective genes to the central nervous system (CNS). In particular, Adeno-Associated Viruses (AAV) have emerged as promising tools for clinical gene transfer in a broad range o...

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Bibliographic Details
Main Authors: Giridhar eMurlidharan, Richard J Samulski, Aravind eAsokan
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00076/full