The in-tissue molecular architecture of β-amyloid pathology in the mammalian brain

The in-tissue molecular architecture of β-amyloid pathology in the mammalian brain

Abstract Amyloid plaques composed of Aβ fibrils are a hallmark of Alzheimer’s disease (AD). However, the molecular architecture of amyloid plaques in the context of fresh mammalian brain tissue is unknown. Here, using cryogenic correlated light and electron tomography we report the in situ molecular...

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Bibliographic Details
Main Authors: Conny Leistner, Martin Wilkinson, Ailidh Burgess, Megan Lovatt, Stanley Goodbody, Yong Xu, Susan Deuchars, Sheena E. Radford, Neil A. Ranson, René A. W. Frank
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38495-5

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https://doi.org/10.1038/s41467-023-38495-5

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