Functional engineering of human iPSC‐derived parasympathetic neurons enhances responsiveness to gastrointestinal hormones

Functional engineering of human iPSC‐derived parasympathetic neurons enhances responsiveness to gastrointestinal hormones

Food‐derived biological signals are transmitted to the brain via peripheral nerves through the paracrine activity of gastrointestinal (GI) hormones. The signal transduction circuit of the brain–gut axis has been analyzed in animals; however, species‐related differences and animal welfare concerns ne...

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Bibliographic Details
Main Authors: Yuka Akagi, Yuzo Takayama, Yuma Nihashi, Azusa Yamashita, Risa Yoshida, Yasuhisa Miyamoto, Yasuyuki S. Kida
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:FEBS Open Bio
Subjects:
brain–gut axis
gastrointestinal hormone
induced pluripotent stem cells
signal transduction
vagus nerve
Online Access:https://doi.org/10.1002/2211-5463.13741

Internet

https://doi.org/10.1002/2211-5463.13741

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