Complement C5a Receptor Signaling Alters Stress Responsiveness and Modulates Microglia Following Chronic Stress Exposure

Complement C5a Receptor Signaling Alters Stress Responsiveness and Modulates Microglia Following Chronic Stress Exposure

Background: Accumulating evidence underscores the pivotal role of heightened inflammation in the pathophysiology of stress-related diseases, but the underlying mechanisms remain elusive. The complement system, a key effector of the innate immune system, produces the C5–cleaved activation product C5a...

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Bibliographic Details
Main Authors: Hsiao-Jou Cortina Chen, Jereme G. Spiers, Titaya Lerskiatiphanich, Sandra E. Parker, Nickolas A. Lavidis, Jenny N. Fung, Trent M. Woodruff, John D. Lee
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Biological Psychiatry Global Open Science
Subjects:
C5a receptor
Complement system
Corticosterone
Glia
Hippocampus
Neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2667174324000193

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http://www.sciencedirect.com/science/article/pii/S2667174324000193

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