No moderating influence of education on the association between changes in hippocampus volume and memory performance in aging
Contemporary accounts of factors that may modify the risk for age-related neurocognitive disorders highlight education and its contribution to a cognitive reserve. By this view, individuals with higher educational attainment should show weaker associations between changes in brain and cognition than...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
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| Series: | Aging Brain |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589958923000191 |
| _version_ | 1827596306980274176 |
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| author | Martin Lövdén Amos Pagin David Bartrés-Faz Carl-Johan Boraxbekk Andreas M. Brandmaier Naiara Demnitz Christian A. Drevon Klaus P. Ebmeier Anders M. Fjell Paolo Ghisletta Tetiana Gorbach Ulman Lindenberger Anna Plachti Kristine B. Walhovd Lars Nyberg |
| author_facet | Martin Lövdén Amos Pagin David Bartrés-Faz Carl-Johan Boraxbekk Andreas M. Brandmaier Naiara Demnitz Christian A. Drevon Klaus P. Ebmeier Anders M. Fjell Paolo Ghisletta Tetiana Gorbach Ulman Lindenberger Anna Plachti Kristine B. Walhovd Lars Nyberg |
| author_sort | Martin Lövdén |
| collection | DOAJ |
| description | Contemporary accounts of factors that may modify the risk for age-related neurocognitive disorders highlight education and its contribution to a cognitive reserve. By this view, individuals with higher educational attainment should show weaker associations between changes in brain and cognition than individuals with lower educational attainment. We tested this prediction in longitudinal data on hippocampus volume and episodic memory from 708 middle-aged and older individuals using local structural equation modeling. This technique does not require categorization of years of education and does not constrain the shape of relationships, thereby maximizing the chances of revealing an effect of education on the hippocampus-memory association. The results showed that the data were plausible under the assumption that there was no influence of education on the association between change in episodic memory and change in hippocampus volume. Restricting the sample to individuals with elevated genetic risk for dementia (APOE ε4 carriers) did not change these results. We conclude that the influence of education on changes in episodic memory and hippocampus volume is inconsistent with predictions by the cognitive reserve theory. |
| first_indexed | 2024-03-09T03:08:44Z |
| format | Article |
| id | doaj.art-1dd55c86ee614390bf39e47325ba3f6a |
| institution | Directory Open Access Journal |
| issn | 2589-9589 |
| language | English |
| last_indexed | 2024-03-09T03:08:44Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aging Brain |
| spelling | doaj.art-1dd55c86ee614390bf39e47325ba3f6a2023-12-04T05:23:53ZengElsevierAging Brain2589-95892023-01-014100082No moderating influence of education on the association between changes in hippocampus volume and memory performance in agingMartin Lövdén0Amos Pagin1David Bartrés-Faz2Carl-Johan Boraxbekk3Andreas M. Brandmaier4Naiara Demnitz5Christian A. Drevon6Klaus P. Ebmeier7Anders M. Fjell8Paolo Ghisletta9Tetiana Gorbach10Ulman Lindenberger11Anna Plachti12Kristine B. Walhovd13Lars Nyberg14Department of Psychology, University of Gothenburg, Gothenburg, Sweden; Corresponding author.Department of Psychology, University of Gothenburg, Gothenburg, SwedenDepartment of Medicine, Faculty of Medicine and Health Sciences and Institute of Neurosciences, University of Barcelona, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, SpainUmeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden; Department of Radiation Sciences, Umeå University, Umeå, Sweden; Danish Research Centre for Magnetic Resonance (DRCMR), Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital – Amager and Hvidovre, Copenhagen, Denmark; Institute for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark; Institute of Sports Medicine Copenhagen (ISMC) and Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, DenmarkCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Department of Psychology, MSB Medical School Berlin, Berlin, GermanyDanish Research Centre for Magnetic Resonance (DRCMR), Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital – Amager and Hvidovre, Copenhagen, DenmarkDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo & Vitas AS, Oslo Science Park, NorwayDepartment of Psychiatry, Warneford Hospital, University of Oxford, UKCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, POB 1094, 0317 Oslo, Norway; ComputationalRadiology and Artificial Intelligence, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Rikshospitalet, NorwayFaculty of Psychology and Educational Sciences, University of Geneva, Switzerland; Faculty of Psychology, UniDistance Suisse, Brig, SwitzerlandDepartment of Integrative Medical Biology, Umeå University, Umeå, SwedenCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, GermanyDanish Research Centre for Magnetic Resonance (DRCMR), Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital – Amager and Hvidovre, Copenhagen, DenmarkCenter for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, POB 1094, 0317 Oslo, Norway; ComputationalRadiology and Artificial Intelligence, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Rikshospitalet, NorwayUmeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden; Department of Radiation Sciences, Umeå University, Umeå, Sweden; Faculty of Psychology and Educational Sciences, University of Geneva, SwitzerlandContemporary accounts of factors that may modify the risk for age-related neurocognitive disorders highlight education and its contribution to a cognitive reserve. By this view, individuals with higher educational attainment should show weaker associations between changes in brain and cognition than individuals with lower educational attainment. We tested this prediction in longitudinal data on hippocampus volume and episodic memory from 708 middle-aged and older individuals using local structural equation modeling. This technique does not require categorization of years of education and does not constrain the shape of relationships, thereby maximizing the chances of revealing an effect of education on the hippocampus-memory association. The results showed that the data were plausible under the assumption that there was no influence of education on the association between change in episodic memory and change in hippocampus volume. Restricting the sample to individuals with elevated genetic risk for dementia (APOE ε4 carriers) did not change these results. We conclude that the influence of education on changes in episodic memory and hippocampus volume is inconsistent with predictions by the cognitive reserve theory.http://www.sciencedirect.com/science/article/pii/S2589958923000191Cognitive reserveBrain maintenanceHippocampusMemoryAging |
| spellingShingle | Martin Lövdén Amos Pagin David Bartrés-Faz Carl-Johan Boraxbekk Andreas M. Brandmaier Naiara Demnitz Christian A. Drevon Klaus P. Ebmeier Anders M. Fjell Paolo Ghisletta Tetiana Gorbach Ulman Lindenberger Anna Plachti Kristine B. Walhovd Lars Nyberg No moderating influence of education on the association between changes in hippocampus volume and memory performance in aging Aging Brain Cognitive reserve Brain maintenance Hippocampus Memory Aging |
| title | No moderating influence of education on the association between changes in hippocampus volume and memory performance in aging |
| title_full | No moderating influence of education on the association between changes in hippocampus volume and memory performance in aging |
| title_fullStr | No moderating influence of education on the association between changes in hippocampus volume and memory performance in aging |
| title_full_unstemmed | No moderating influence of education on the association between changes in hippocampus volume and memory performance in aging |
| title_short | No moderating influence of education on the association between changes in hippocampus volume and memory performance in aging |
| title_sort | no moderating influence of education on the association between changes in hippocampus volume and memory performance in aging |
| topic | Cognitive reserve Brain maintenance Hippocampus Memory Aging |
| url | http://www.sciencedirect.com/science/article/pii/S2589958923000191 |
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