The preliminary study suggests an association between NF-ĸB pathway activation and increased plasma 20S proteasome activity in intracranial aneurysm patients

The preliminary study suggests an association between NF-ĸB pathway activation and increased plasma 20S proteasome activity in intracranial aneurysm patients

Abstract The significant role of increased activation of 20S proteasomes in the development of abdominal aortic aneurysms has been well-established in a mouse model. The available literature lacks similar studies concerning brain aneurysms. The aim of the study was to verify the hypothesis that pati...

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Bibliographic Details
Main Authors: Joanna Kamińska, Marzena Tylicka, Kinga Sutkowska, Karolina Marta Gacuta, Magdalena Maria Sawicka, Ewa Kowalewska, Magdalena Ćwiklińska-Dworakowska, Mateusz Maciejczyk, Tomasz Łysoń, Johannes Kornhuber, Piotr Lewczuk, Joanna Matowicka-Karna, Olga Martyna Koper-Lenkiewicz
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Subjects:
Intracranial aneurysms (IA)
20S proteasome
Canonical NF-κB pathway
NF-κB1
NF-κB2
NF-κB p65
Online Access:https://doi.org/10.1038/s41598-024-54692-8

Internet

https://doi.org/10.1038/s41598-024-54692-8

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